Revoking a user ID is a fairly similar process, except that it uses the key_revoke_uid method.

import gpg c = gpg.Context() c.home_dir = "~/.gnupg-dm" dmfpr = "177B7C25DB99745EE2EE13ED026D2F19E99E63AA" key = c.get_key(dmfpr, secret=True) uid = "Danger Mouse <danger.mouse@secret.example.net>" c.key_revoke_uid(key, uid)